QT Interval Is Linked to 2 Long-QT Syndrome Loci in Normal Subjects
نویسندگان
چکیده
منابع مشابه
QT interval is linked to 2 long-QT syndrome loci in normal subjects.
BACKGROUND The rate-corrected QT interval (QTc) is heritable, and the discovery of quantitative trait loci that influence the QTc would be an important step in identifying the genes responsible for life-threatening arrhythmias in the general population. We studied 66 pairs of unselected normal dizygotic (DZ) twin subjects and their parents in a sib-pair analysis. We tested for linkage of gene l...
متن کامل[The long QT interval syndrome].
The syndrome of long QT interval frequently follows to syncope or a sudden cardiac death on the basis of originated polymorphic ventricular tachycardia of the "torsade de pointes" type. The prolongation of the QT interval in the hereditary form is based on mutation of the genes responsible for the formation of sodium and potassium channels. The authors analyze the occurrence, clinical findings,...
متن کاملAutonomic nervous system influences on QT interval in normal subjects.
OBJECTIVES We sought to determine whether the relationship between heart rate (HR) and QT interval (QT) differs as HR increases in response to exercise, atropine and isoproterenol. BACKGROUND Autonomic nervous system influences on repolarization are poorly understood and may complicate the interpretation of QT measurements. METHODS Twenty-five normal subjects sequentially underwent graded-i...
متن کاملAbnormal QT responses to adenosine in subjects with long-QT syndrome.
In the interesting article by Viskin et al., adenosine-induced bradycardia was found to produce a higher increase in QT and a lower decrease in QTc (calculated using the Bazett formula) in subjects with long-QT syndrome (LQTS) than in controls. However, a major issue in this study concerns the reliability of QT correction when large ranges of heart rates are analysed. The Bazett formula overcor...
متن کاملQT interval: how to measure it and what is "normal".
Abnormally long and short QT intervals have been shown to be associated with an increased risk for life-threatening ventricular arrhythmias and sudden cardiac death. In recent years, various methods for QT-interval measurement have been developed, including individual-based corrections for repolarization duration, quantitative assessment of repolarization morphology, correction for repolarizati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.99.24.3161